Effect of crocus sativus on gentamicin induced nephrotoxicity
| Autor: | MARJAN AJAMI, SHAHRIAR EGHTESADI, HAMIDREZA PAZOKI-TOROUDI, ROUHOLLAH HABIBEY, SOLTAN AHMED EBRAHIMI |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Biological Research, Vol 43, Iss 1, Pp 83-90 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0716-9760 0717-6287 |
| Popis: | Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced severe histological changes. Saffron at 40 mg/k/d significantly reduced gentamicin-induced increases in BUN and histological scores (p |
| Databáze: | Directory of Open Access Journals |
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