Association Between Sex Hormone-Binding Globulin, Atherogenic Indices of Plasma Among Young Sedentary Males

Autor: Ali Mohammadrezaei, Abnoos Mokhtari Ardekani, Mahdieh Abbasalizad-Farhangi, Mehran Mesgari-Abbasi, Reihaneh Mousavi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nutrition and Metabolic Insights, Vol 16 (2023)
Druh dokumentu: article
ISSN: 1178-6388
11786388
DOI: 10.1177/11786388231155006
Popis: Background: Males are more likely than females to suffer from cardiovascular disease (CVD). So, sex hormones may modify these variations and affect the lipid profile. We examined the relationship between sex hormone-binding globulin (SHBG) and CVD risk factors among young males in this study. Methods: Using a cross-sectional design, we measured total testosterone, SHBG, lipids, glucose, insulin, antioxidant parameters, and anthropometric factors in 48 young males in the age range of 18 to 40 years. Atherogenic indices of plasma were calculated. In this study, a partial correlation analysis was carried out to assess the relationship between SHBG and other variables after adjustment for confounders. Results: According to the results of multivariable analyses adjusted for age and energy, SHBG had a negative correlation with total cholesterol ( r = −.454, P =.010), low-density lipoprotein cholesterol ( r = −.496, P =.005), quantitative insulin-sensitivity check index, and positive correlation with high-density lipoprotein cholesterol ( r = .463, P =.009). No significant correlation was observed between SHBG and triglycerides ( P >.05). Several atherogenic indices of plasma have a negative correlation with SHBG levels. These include Atherogenic Index of Plasma ( r = −.474, P = .006), Castelli Risk Index (CRI)1 ( r = −.581, P
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