Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

Autor: Karel Šmejkal, Tereza Šlapetová, Pavel Krmenčík, Renata Kubínová, Pavel Suchý, Stefano Dall´Acqua, Gabbriella Innocenti, Ján Vančo, Karolína Kalvarová, Margita Dvorská, Jiří Slanina, Eva Kramářová, Jan Muselík, Milan Žemlička
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Molecules, Vol 15, Iss 3, Pp 1223-1231 (2010)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules15031223
Popis: The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
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