A Phase 3 Study of Enarodustat (JTZ-951) in Japanese Hemodialysis Patients for Treatment of Anemia in Chronic Kidney Disease: SYMPHONY HD Study

Autor:	Tadao Akizawa, Masaomi Nangaku, Takuhiro Yamaguchi, Ryosuke Koretomo, Kazuo Maeda, Yuya Miyazawa, Hideki Hirakata
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	enarodustat anemia in chronic kidney disease hypoxia-inducible factor-prolyl hydroxylase inhibitor iron utilization phase 3 study Internal medicine RC31-1245
Zdroj:	Kidney Diseases, Pp 1-9 (2021)
Druh dokumentu:	article
ISSN:	2296-9381 2296-9357 00051705
DOI:	10.1159/000517053
Popis:	Introduction: Enarodustat (JTZ-951) is a new oral hypoxia-inducible factor-prolyl hydroxylase inhibitor for the treatment of anemia in chronic kidney disease (CKD). We conducted a phase 3 study to compare the efficacy and safety of enarodustat with darbepoetin alfa (DA) in Japanese anemic patients with CKD receiving maintenance hemodialysis. Methods: Subjects receiving maintenance hemodialysis were randomly assigned at a 1:1 ratio to receive oral enarodustat once daily or intravenous DA every week for 24 weeks with dose adjustment every 4 weeks to maintain hemoglobin (Hb) within a target range (≥10.0 to
Databáze:	Directory of Open Access Journals
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