VirMutSig: Discovery and assignment of viral mutational signatures from sequencing data

Autor:	Davide Maspero, Fabrizio Angaroni, Danilo Porro, Rocco Piazza, Alex Graudenzi, Daniele Ramazzotti
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Bioinformatics Sequence analysis Genomics Sequencing RNAseq Systems biology Science (General) Q1-390
Zdroj:	STAR Protocols, Vol 2, Iss 4, Pp 100911- (2021)
Druh dokumentu:	article
ISSN:	2666-1667 27459799
DOI:	10.1016/j.xpro.2021.100911
Popis:	Summary: We describe the procedures to perform the following: (1) the de novo discovery of mutational signatures from raw sequencing data of viral samples and (2) the association of existing viral mutational signatures to the samples of a given dataset. The goal is to identify and characterize the nucleotide substitution patterns related to the mutational processes that underlie the origination of variants in viral genomes. The VirMutSig protocol is available at this link: https://github.com/BIMIB-DISCo/VirMutSig.For complete information on the theoretical aspects of this protocol, please refer to Graudenzi et al. (2021).
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c7552eea9d2745979940a9fa04da0090 Zobrazit plný text záznamu View record in DOAJ