Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing

Autor: Aaron Snoberger, Evan J. Brettrager, David M. Smith
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04731-6
Popis: Proteasomal ATPases contain functionally important coiled-coil (CC) domains, the mechanistic role of which is not fully understood. Here, the authors provide evidence for three distinct CC conformations, showing that CC conformational changes enable ATPases to switch between active and resting states.
Databáze: Directory of Open Access Journals