Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy

Autor: Xavier Montané, Oliwia Kowalczyk, Belen Reig-Vano, Anna Bajek, Krzysztof Roszkowski, Remigiusz Tomczyk, Wojciech Pawliszak, Marta Giamberini, Agnieszka Mocek-Płóciniak, Bartosz Tylkowski
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecules, Vol 25, Iss 15, p 3342 (2020)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules25153342
Popis: The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs—which are usually more aggressive than natural compounds—with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.
Databáze: Directory of Open Access Journals
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