| Autor: |
Renzo Manara, Sara Ponticorvo, Immacolata Tartaglione, Gianluca Femina, Andrea Elefante, Camilla Russo, Pasquale Alessandro Carafa, Mario Cirillo, Maddalena Casale, Angela Ciancio, Rosanna Di Concilio, Elisa De Michele, Nikolaus Weiskopf, Francesco Di Salle, Silverio Perrotta, Fabrizio Esposito |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 24, Iss , Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2019.102058 |
| Popis: |
Objective: Multisystem iron poisoning is a major concern for long-term beta-thalassemia management. Quantitative MRI-based techniques routinely show iron overload in heart, liver, endocrine glands and kidneys. However, data on the brain are conflicting and monitoring of brain iron content is still matter of debate. Methods: This 3T-MRI study applied a well validated high-resolution whole-brain quantitative MRI assessment of iron content on 47 transfusion-dependent (mean-age: 36.9 ± 10.3 years, 63% females), 23 non-transfusion dependent (mean-age: 29.2 ± 11.7 years, 56% females) and 57 healthy controls (mean-age: 33.9 ± 10.8 years, 65% females). Clinical data, Wechsler Adult Intelligence Scale scores and treatment regimens were recorded. Beside whole-brain R2* analyses, regional R2*-values were extracted in putamen, globus pallidum, caudate nucleus, thalamus and red nucleus; hippocampal volumes were also determined. Results: Regional analyses yielded no significant differences between patients and controls, except in those treated with deferiprone that showed lower R2*-values (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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