| Autor: |
Paolo De Simone, Paola Carrai, Giulia Leonardi, Alessandro Silvestri, Davide Ghinolfi, Arianna Precisi, Daniela Campani, Franco Filipponi |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
European Medical Journal Hepatology, Vol 2, Iss 1, Pp 77-85 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2053-4221 |
| Popis: |
Hepatitis B surface antigen (HBsAg) quantification has recently been introduced to guide treatment in chronic hepatitis B virus (HBV) patients. No information is currently available on use of HBsAg levels to guide HBV immune globulin (HBIG) administration after liver transplantation (LT). We performed a retrospective analysis of a prospectively collected database. Patients were included if: adults (≥18 years); recipients of a primary liver graft; HBsAg-positive and HBV DNA-negative at transplantation; hepatitis C and/or HIV-negative; not transplanted for fulminant hepatic failure; on nucleoside analogues. All patients were administered 30,000 IU HBIG, perioperatively, and hepatitis B surface antibody (HBsAb) was tested at day 7, 14, 28, and monthly thereafter. A further 30,000 HBIG were administered if HBsAb 100 IU/mL on day 7. The primary endpoint was the efficacy of HBIG as a percentage of patients achieving HBsAg |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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