Effectiveness of biosimilar pegfilgrastim in patients with lymphoma after high-dose chemotherapy and autologous stem cell transplantation: a real-life study

Autor: Barbara Loteta, Annalisa Pitino, Martina Pitea, Caterina Alati, Giovanni Tripepi, Maria Caterina Mico', Maria Pellicano', Francesca Cogliandro, Gaetana Porto, Giorgia Policastro, Giovanna Utano, Ilaria Maria Delfino, Annalisa Sgarlata, Anna Scopelliti, Aurora Idato, Giovanni Laenza, Maria Altomonte, Graziella D'Arrigo, Mercedes Gori, Massimo Martino
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Hematology, Vol 3 (2024)
Druh dokumentu: article
ISSN: 2813-3935
DOI: 10.3389/frhem.2024.1441070
Popis: ObjectivesTo evaluate the efficacy of biosimilar (BIO) pegfilgrastim (PEG) in lymphoma patients after autologous stem cell transplantation (ASCT).Methods86 consecutive lymphoma patients who received BIO/PEG after ASCT were assessed. The primary endpoints of this study were the incidence of febrile neutropenia (FN) and time to neutrophil engraftment.ResultsMost patients were males (67.4%) with a median age of 48 years. FN occurred in 66 patients (76.7%), and most of the fever was grade 1-2. The median time to neutrophil engraftment was 9 days. The incidence of FN differs based on lymphoma type (p-value
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