Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort

Autor:	Piero Ruscitti, Damiano Currado, Felice Rivellese, Marta Vomero, Luca Navarini, Paola Cipriani, Costantino Pitzalis, Roberto Giacomelli
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Rheumatoid arthritis Type 2 diabetes IL-1β ubiquitin Synovial biopsy Pathobiology Of Early Arthritis Cohort study (PEAC) Diseases of the musculoskeletal system RC925-935
Zdroj:	Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	1478-6362
DOI:	10.1186/s13075-024-03392-9
Popis:	Abstract Objective Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes (T2D), we evaluated the synovial tissue expression of IL-1 related genes in relationship to the ubiquitin–proteasome system and the effects of insulin on ubiquitinated proteins in fibroblast-like synoviocytes (FLSs). Methods The synovial expression of IL-1 pathway genes was compared in early (
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/75194bde7dd246e9b0525addd9e6fd14 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ