Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus

Autor:	Takeshi Yamada, Mayo Suzue, Takanobu Arai, Takashi Kikuchi, Reiko Tanaka
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	trichodermanins Trichoderma harzianum marine microorganism Halichondria okadai diterpenes 6-5-6-6 ring system cytotoxicity Biology (General) QH301-705.5
Zdroj:	Marine Drugs, Vol 15, Iss 6, p 169 (2017)
Druh dokumentu:	article
ISSN:	1660-3397
DOI:	10.3390/md15060169
Popis:	Trichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher’s method. In addition, 1 inhibited the growth of cancer cell lines potently.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/751587abebca4c81a4ecb12ec8f7f95a Zobrazit plný text záznamu View record in DOAJ