| Autor: |
Tung Phi Nguyen, Xuan Thi Phan, Tuan Huu Nguyen, Dai Quang Huynh, Linh Thanh Tran, Huy Minh Pham, Tu Ngoc Nguyen, Hieu Trung Kieu, Thao Thi Ngoc Pham |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Critical Care Research and Practice, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2090-1313 |
| DOI: |
10.1155/2022/5348835 |
| Popis: |
Background. Major bleeding has been a common and serious complication with poor outcomes in ECMO patients. With a novel, less-invasive cannulation approach and closer coagulation monitoring regime, the incidence of major bleeding is currently not determined yet. Our study aims to examine the incidence of major bleeding, its determinants, and association with mortality in peripheral-ECMO patients. Method. We conducted a single-center retrospective study on adult patients undergoing peripheral-ECMO between January 2019 and January 2020 at a tertiary referral hospital. Determinants of major bleeding were defined by logistic regression analysis. Risk factors of in-hospital mortality were determined by Cox proportional hazard regression analysis. Results. Major bleeding was reported in 33/105 patients (31.4%) and was associated with higher in-hospital mortality [adjusted hazard ratio (aHR) 3.56, 95% confidence interval (CI) 1.63–7.80, p72 seconds [adjusted odds ratio (aOR) 7.10, 95% CI 2.60–19.50, p220 seconds [aOR = 3.9, 95% CI 1.20–11.80, p=0.017] on days with major bleeding were independent predictors. Conclusions. In summary, major bleeding still had a fairly high incidence and poor outcome in peripheral-ECMO patients. APTT > 72 seconds, fibrinogen |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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