Role of T-Helper 9 Cells in Chronic Hepatitis C-Infected Patients

Autor: Mohamed E. Ali, Omnia El-Badawy, Noha A. Afifi, Abeer Sharaf Eldin, Elham Ahmed Hassan, Hamada M. Halby, Mohamed Ahmed El-Mokhtar
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Viruses, Vol 10, Iss 7, p 341 (2018)
Druh dokumentu: article
ISSN: 1999-4915
78177480
DOI: 10.3390/v10070341
Popis: Hepatitis C virus is a hepatotropic virus that is transmitted parenterally. Viral infections are usually associated with modulations of the immune cells, leading to enhanced viral survival and spreading, and accordingly, life-threatening complications. Recently, it has been proposed that a new subset of T-helper, named T-helper 9, is involved in the pathogenesis of different immunopathological conditions, such as allergies, tumors, and viral infections. Some studies reported a protective role, and others described a pathogenic potential for the T-helper 9 cells. Here, we present evidence that T-helper 9 cells are dynamically increased with increasing the pathogenic strategy for hepatitis C virus (HCV). Furthermore, viral clearance is associated with a decrease in T-helper 9. The increase in T-helper 9 was paralleled with an increase in its receptor expression. Taken together, our data suggest that T-helper 9 cells play an important role in the pathogenesis of HCV, and is directly associated with HCV-related complications.
Databáze: Directory of Open Access Journals
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