Water transport through rat colonic epithelium during ceftriaxone therapy
| Autor: | T. Dovbynchuk, T. Beregova, H. Tolstanova, L. Zakordonets |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ, Vol 68, Iss 3, Pp 29-33 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1728-2748 2308-8036 |
| DOI: | 10.17721/1728_2748.2014.68.29-33 |
| Popis: | The dose and time-depended effect of the antibiotic ceftriaxone on net water transport in rat colonic epithelium was studied by colonic loop perfusion technique in situ. Ceftriaxone in dose 50 mg / kg / day caused diarrhea in 10% of rats, in dose 300 mg/kg/day – 25% of rats. Ceftriaxone in both doses decreased net water absorption in rat colon. The resulting effect was more pronounced after 14-days course compared with 5-days. |
| Databáze: | Directory of Open Access Journals |
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