Antibiotic resistance of Helicobacter pylori in the European part of the Russian Federation: first results
| Autor: | I. V. Maev, D. N. Andreev, V. M. Govorun, E. N. Ilina, Yu. A. Kucheryavyy, T. S. Oganesian, E. V. Melnikova, O. V. Zayratyants, T. V. Parfenova, L. V. Dzhedzheia, N. V. Kirillova, E. A. Maevskaya, A. K. Fomenko, E. G. Lobanova, A. V. Zaborovskii, K. A. Kriukov |
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| Jazyk: | ruština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 92, Iss 8, Pp 24-28 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 00403660 |
| DOI: | 10.26442/00403660.2020.08.000761 |
| Popis: | Aim. Determine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in the European part of the Russian Federation. Materials and methods. As part of a clinical laboratory study, from 2015 to 2018, 27 gastrobiopsy samples obtained from H. pylori-infected patients were analyzed. H. pylori infection was verified using a rapid urease test or a 13C-urea breath test. The values of the minimum inhibitory concentration (MIC) of antibiotics were determined by the diffusion method using E-test strips (BioMerieux, France) according to the recommendations of the manufacturer. The sensitivity of the isolates was determined for 6 antibacterial drugs (amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifampicin). Results. According to the data obtained, resistance to amoxicillin was 0%, clarithromycin 11.1%, metronidazole 59.3%, levofloxacin 3.7%, tetracycline 0%, and rifampicin 14.8%. Dual resistance to clarithromycin and metronidazole was recorded in two isolates (7.4%). Conclusion. Thus, the first results of the evaluation of H. pylori antibiotic resistance in the European part of the Russian Federation indicate a low resistance of the microorganism to clarithromycin and quite high to metronidazole. |
| Databáze: | Directory of Open Access Journals |
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