Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization

Autor: Hualing Zhai, Chi Chen, Ningjian Wang, Yi Chen, Xiaomin Nie, Bing Han, Qin Li, Fangzhen Xia, Yingli Lu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Environmental Health, Vol 16, Iss 1, Pp 1-9 (2017)
Druh dokumentu: article
ISSN: 1476-069X
DOI: 10.1186/s12940-017-0304-7
Popis: Abstract Background China has undergone rapid urbanization in the past three decades. We aimed to report blood lead level (B-Pb) in the most rapidly urbanized Yangtze River Delta Region of China, and explore the association B-Pb and non-alcoholic fatty liver disease (NAFLD). Methods Our data source was the SPECT-China study. We enrolled 2011 subjects from 6 villages in the Yangtze River Delta Region. Lead was measured by atomic absorption spectrometry. According to abdominal ultrasound, residents were divided into normal and NAFLD groups. Results In total, 824 (41.0%) were diagnosed with NAFLD. Medians (interquartile range) of B-Pb were 5.29 μg/dL (3.60–7.28) [0.25 μmol/L (0.17–0.35)] for men and 4.49 μg/dL (2.97–6.59) [0.22 μmol/L (0.14–0.32)] for women. In both genders, the NAFLD group had significantly greater B-Pb than normal group (both P
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