Prognostic Significance of the Cachexia Index in Patients with Non-Small-Cell Lung Cancer and Brain Metastases after Stereotactic Radiotherapy

Autor: Hui Xu, Bin Zhang, Yongqian Zhang, Chunchun Yang, Changwen Bo, Yuanyuan Guo, Yuan Cheng, Li He
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical Medicine Insights: Oncology, Vol 18 (2024)
Druh dokumentu: article
ISSN: 1179-5549
11795549
DOI: 10.1177/11795549231222362
Popis: Background: The cachexia index (CXI) has been proposed as a novel biomarker of cancer cachexia. We aimed to investigate the association between CXI and survival outcomes after stereotactic radiotherapy (SRT) in patients with non-small cell lung cancer (NSCLC) and brain metastases. Methods: Data from 145 patients with NSCLC, who underwent SRT for brain metastases between April 2016 and August 2020, were retrospectively analyzed. Cachexia index was calculated as skeletal muscle index (SMI) × serum albumin level/neutrophil-to-lymphocyte ratio, whereas SMI was calculated from computed tomography images captured at the L1 level. Kaplan-Meier curves and Cox proportional hazards models were used to assess progression-free survival (PFS) and overall survival (OS). The prognostic values of CXI and other cachexia biomarkers were assessed using receiver operating characteristic (ROC) curve analysis. Results: Lower pretreatment CXI (
Databáze: Directory of Open Access Journals
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