A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

Autor: Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Fumitake Kondo, Toshihiro Yamamoto, Mie Kurata, Hiroshi Fujiwara, Junya Masumoto, Katsuto Takenaka, Masaki Yasukawa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2399-3642
74851128
DOI: 10.1038/s42003-021-01791-1
Popis: With the aim of optimizing CAR-T cells for immunotherapy, Ochi et al. have established a system to generate and screen a library of CAR-T cells expressing different immunoglobulin variable regions. They show that this approach can enhance anti-tumour activities of CAR-T cells in vivo.
Databáze: Directory of Open Access Journals
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