Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
| Autor: | Abelardo Loya-Solis, Lucía Alemán-Meza, Luis Carlos Canales-Martínez, Rodolfo Franco-Márquez, Alim Adriana Rincón-Bahena, Karla María Nuñez-Barragán, Raquel Garza-Guajardo, Marco Antonio Ponce-Camacho |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Case Reports in Pathology, Vol 2015 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2090-6781 2090-679X |
| DOI: | 10.1155/2015/841237 |
| Popis: | Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free. |
| Databáze: | Directory of Open Access Journals |
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