| Autor: |
N.L. Cruden, N.N. Lang, T.J. MacGillivray, N.G. Uren, K.A. Fox, D.E. Newby |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Artery Research, Vol 3, Iss 4 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2009.10.052 |
| Popis: |
Background: Vascular B1 kinin receptor expression is upregulated in human atheroma and the presence of angiotensin-converting enzyme inhibition (ACEi), but its role in man remains unclear. We examined vasomotor and fibrinolytic responses to selective kinin receptor agonism in the human femoral circulation and correlated responses with femoral arterial plaque load. Methods: Femoral arterial cross sectional area, blood flow and plaque volume were determined using intravascular ultrasound and a Doppler Flowire during selective femoral arterial infusion of Lys-des-Arg9-Bradykinin (B1 agonist; 3, 10, 30 nmol/min), bradykinin (B2 agonist; 100, 300, 1000 pmol/min) and sodium nitroprusside (6, 12, 24 mcg/min) in eleven patients undergoing diagnostic coronary angiography, in the presence and absence of ACEi. Tissue plasminogen activator (t-PA) release was measured across the femoral vascular bed. Results: Mean femoral arterial plaque load was 7.0±0.9mm3 per mm of vessel. Bradykinin and nitroprusside caused dose-dependent increases in femoral blood flow (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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