'Good Fences Make Good Neighbors': How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

Autor:	Woojung Shin, Landon A. Hackley, Hyun Jung Kim
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	gut inflammation-on-a-chip gut-on-a-chip microphysiological system microbiome barrier function inflammation oxidative stress disease model host-microbiome interaction probiotics Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gut Microbes, Vol 11, Iss 3, Pp 581-586 (2020)
Druh dokumentu:	article
ISSN:	1949-0976 1949-0984 19490976
DOI:	10.1080/19490976.2019.1626684
Popis:	A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro. The modular accessibility and modularity of the microphysiological gut-on-a-chip can lead to the identification of the seminal trigger in intestinal inflammation. By coupling microbial and immune cells in a spatiotemporal manner, we discovered that the maintenance of healthy epithelial barrier function is necessary and sufficient to demonstrate the homeostatic tolerance of the gut. Here, we highlight the breakthrough of our new disease model and discuss the future impact of investigating the etiology and therapeutic targets in the multifactorial inflammatory bowel disease.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/744e4ba644454f33826d56b9863ac4ba Zobrazit plný text záznamu View record in DOAJ