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Background: Vascular load is an important determinant of ventricular function. Understanding the physiologic basis of vascular load is central to the development of new strategies and drugs to treat HF. Aim: to evaluate arterial stiffness, endothelial function, clinical status at baseline and in 6 months follow-up period of perindopril therapy in diastolic HF. Methods: 40 patients with exertional dyspnea, I-II NYHA, EF>45%, aged 62(8,4) years, F/M=27/13, history of CHF 29(16) months, BMI 29,4kg/m2. Arterial stiffness was assessed by measuring carotid-femoral PWV and central: mean BP(MAP), pulse pressure(CPP), AIX using applanation tonometry (Sphygmocor) at the baseline and in 6-months f-up. Endothelial dysfunction using FMD during reactive hyperemia (HDI 5000), clinical status with MQLHF were assessed at the baseline and in 6-months f-up period. All patients were on perindopril therapy, mean dose 8mg/day. Results: Baseline 6months f-up p PWV 10(8,6;11,9) 9(8,3;11,5) =0.06 CSBP 135(123;152) 132(124;140) ns CDBP 85(79;93) 82(80,5;90) ns SBP 145(134;154) 131(126;142) |
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