Influence of bile acids on the adsorption of lidocaine and verapamil in an in vitro experiment
| Autor: | MIHALJ M. POŠA, KSENIJA N. KUHAJDA |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 75, Iss 4, Pp 433-440 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 86762206 |
| Popis: | The work is concerned with the influence of the structure of bile acids (cholic, deoxycholic, chenodeoxycholic, and their keto derivatives) on the in vitro adsorption of lidocaine and verapamil from an aqueous phase to rat’s intestine membrane. Transport of lidocaine from an aqueous medium to the rat’s intestine membrane was significantly increased (p < 0.05) only by 7-ketodeoxycholic acid, whereas an analogous increase in verapamil transport was produced only by cholic acid. It appeared that, of all the tested bile acids, these two acids form the most stable complexes (by hydrogen bonds) with the respective drug. |
| Databáze: | Directory of Open Access Journals |
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