Genome-wide chromatin accessibility is restricted by ANP32E

Autor: Kristin E. Murphy, Fanju W. Meng, Claire E. Makowski, Patrick J. Murphy
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18821-x
Popis: Chromatin state underlies cellular function, and transcription factor binding patterns along with epigenetic marks define chromatin state. Here the authors show that the histone chaperone ANP32E functions through regulation of H2A.Z to restrict genome-wide chromatin accessibility and to inhibit gene transcriptional activation.
Databáze: Directory of Open Access Journals