| Autor: |
Meng-Chang Lee, Nai-Hua Chen, Nien-Tzu Liu, Wen Su, Chun-Cheng Liao, Sui-Lung Su |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Medical Sciences, Vol 44, Iss 1, Pp 31-38 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1011-4564 |
| DOI: |
10.4103/jmedsci.jmedsci_110_23 |
| Popis: |
Background: Hemodialysis (HD) is a public health issue, and HD-induced infection is a major risk factor for mortality. Toll-like receptor 4 (TLR4) plays a key role in the pathogenesis of infection. However, polymorphisms of TLR4 contribute to infection are still unknown. Aim: This study aimed to examine the correlation between polymorphisms of TLR4 and mortality among HD patients. Methods: This retrospective cohort study included 585 participants from Tri-Service General Hospital in Taipei from 2011 to 2015. All participants were genotyped for TLR4 rs10116253T/C and rs7873784G/C by the iPLEX Gold single-nucleotide polymorphisms assay. Analysis of the conditional Cox proportional hazard model was used to test the association between TLR4 polymorphisms and mortality. Results: Our results show that adjustment with age and gender, TLR4 rs10116253T/C demonstrates an association with mortality (hazard ratio [HR] =1.38, 95% confidence interval [CI] =1.00–1.89) in a dominant model, especially in infection-related mortality (HR = 2.14, 95% CI = 1.04–4.43) of HD patients. Conclusion: The results demonstrate that TLR4 rs10116253T/C may play a role in the etiology of infection among HD patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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