| Autor: |
Milanović, Žiko B., Marković, Zoran S., Dimić, Dušan S., Klisurić, Olivera R., Radojević, Ivana D., Šeklić, Dragana S., Živanović, Marko N., Marković, Jasmina Dimitrić, Radulović, Milanka, Avdović, Edina H. |
| Jazyk: |
English<br />French |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Comptes Rendus. Chimie, Vol 24, Iss 2, Pp 215-232 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1878-1543 |
| DOI: |
10.5802/crchim.68 |
| Popis: |
In the present manuscript, three different 4,7-dihydroxycoumarin derivatives were prepared and structurally characterized by crystallographic and spectroscopic techniques in combination with the B3LYP-D3BJ theoretical method. Cytotoxic and antimicrobial activities of investigated compounds were screened against different cell lines and microorganisms. HCT-116 cells were most sensitive to the 3-(1-(2-hydroxyphenyl)amino) ethylidene)-2,4-dioxochroman-7-yl acetate derivative, while the best antimicrobial activity against Bacillus subtilis ATCC 6633 was shown by 3-(1-(2-hydroxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl acetate. The molecular docking study for all compounds with important epidermal growth factor receptors (EGFR) was performed. The results indicate that the largest contribution to the binding energy is through conventional hydrogen bonds. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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