Three new lignan glucosides from the roots of Scutellaria baicalensis

Autor:	Hailin Long, Haijing Zhang, Anjun Deng, Lin Ma, Lianqiu Wu, Zhihong Li, Zhihui Zhang, Wenjie Wang, Jiandong Jiang, Hailin Qin
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Scutellaria baicalensis Roots Labiatae Lignan glucoside Baicalensinosides A–C 3 4-Dibenzyltetrahydrofuran Osteoprotegerin-activating activity Anti-osteoporotic activity Therapeutics. Pharmacology RM1-950
Zdroj:	Acta Pharmaceutica Sinica B, Vol 6, Iss 3, Pp 229-233 (2016)
Druh dokumentu:	article
ISSN:	2211-3835 2211-3843
DOI:	10.1016/j.apsb.2016.03.007
Popis:	Three new lignan glucosides, baicalensinosides A–C (1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7′-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/741d0ec2a96c43d0906ccf057dddc932 Zobrazit plný text záznamu View record in DOAJ