Autor: |
Yazan Haddad, Marketa Charousova, Hana Zivotska, Zbynek Splichal, Miguel Angel Merlos Rodrigo, Hana Michalkova, Sona Krizkova, Barbora Tesarova, Lukas Richtera, Petr Vitek, Kamila Stokowa-Soltys, David Hynek, Vedran Milosavljevic, Simona Rex, Zbynek Heger |
Jazyk: |
angličtina |
Rok vydání: |
2020 |
Předmět: |
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Zdroj: |
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-20 (2020) |
Druh dokumentu: |
article |
ISSN: |
1477-3155 |
DOI: |
10.1186/s12951-020-00654-x |
Popis: |
Abstract Background Currently, the diagnosis and treatment of neuroblastomas—the most frequent solid tumors in children—exploit the norepinephrine transporter (hNET) via radiolabeled norepinephrine analogs. We aim to develop a nanomedicine-based strategy towards precision therapy by targeting hNET cell-surface protein with hNET-derived homing peptides. Results The peptides (seq. GASNGINAYL and SLWERLAYGI) were shown to bind high-resolution homology models of hNET in silico. In particular, one unique binding site has marked the sequence and structural similarities of both peptides, while most of the contribution to the interaction was attributed to the electrostatic energy of Asn and Arg ( |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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