RNA-Seq profiling of circular RNAs in human laryngeal squamous cell carcinomas

Autor: Cheng Lu, Xi Shi, Amanda Y. Wang, Yuan Tao, Zhenxiao Wang, Chaoping Huang, Yuehua Qiao, Hongyi Hu, Liangfa Liu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Molecular Cancer, Vol 17, Iss 1, Pp 1-9 (2018)
Druh dokumentu: article
ISSN: 1476-4598
DOI: 10.1186/s12943-018-0833-x
Popis: Abstract Abnormal expression of non-coding circular RNAs (circRNAs) have been reported in many types of tumors. circRNA have been suggested to be an ideal candidate biomarker for diagnostic and therapeutic implications in cancers. The aim of this study was to assess the circRNA expression profile of laryngeal squamous cell carcinomas (LSCC). The biopsy samples from patients with LSCC were obtained intra-operatively. The circRNA expression was performed using secondary sequencing. Among 10 patients with LSCC, 2 were well differentiated, 3 were moderately differentiated and 5 were adjunctive samples with normal and LSCC tissues. A total of 21,444 distinct circRNA candidates were detected. Among them, we defined the statistical criteria for selecting aberrant-expressed circRNA using a q-value of 2.0 or
Databáze: Directory of Open Access Journals
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