A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology
| Autor: | Jenny Sprooten, An Coosemans, Abhishek D. Garg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
immunosurveillance
anticancer immunity inhibitory receptors lymphocytes benign or borderline lesions immunology neutrophils wound healing tgfb1 pattern-recognition receptors (prrs) ovarian canc er Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| Zdroj: | OncoImmunology, Vol 11, Iss 1 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2162-402X 2162402X |
| DOI: | 10.1080/2162402X.2021.2024692 |
| Popis: | Non-invasive, immuno-dynamic, biomarkers positioned in cancer patient’s blood milieu with immuno-oncological applications are rare. We recently established a “first-in-class” serum functional immunodynamics status (sFIS) assay, wherein in vitro assessment of serum-induced myeloid NFkB and/or interferon (IFN) response-signaling can be performed to “mimic” in situ patient’s serum immune-biology. This modality has clear implications for anticipating patient prognosis and immunotherapy-relevant stratification. |
| Databáze: | Directory of Open Access Journals |
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