A Novel Assisted Oocyte Activation Method Improves Fertilization in Patients With Recurrent Fertilization Failure

Autor: Meng Wang, Lixia Zhu, Chang Liu, Hui He, Cheng Wang, Chenxi Xing, Jinming Liu, Liu Yang, Qingsong Xi, Zhou Li, Lei Jin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Druh dokumentu: article
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.672081
Popis: Total fertilization failure (TFF) occurs in 1–3% of total intracytoplasmic sperm injection (ICSI) cycles and can reoccur in subsequent cycles. Despite the high success rate with the application of assisted oocyte activation (AOA), there is still a small number of couples who cannot obtain fertilized eggs after conventional calcium (Ca2+) ionophores-based ICSI-AOA. Six couples experiencing repeated TFF or low fertilization (
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