Uric acid and risk of gestational diabetes mellitus: an observational study and mendelian randomization analysis

Autor:	Nuerbiya Xilifu, Rui Zhang, Yongling Dai, Miyeshaer Maimaiti, Zhangyan Li, Ju Yang, Shufei Zang, Jun Liu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Early pregnancy uric acid (UA) Gestational diabetes mellitus (GDM) Mendelian randomization analysis (MR) Gynecology and obstetrics RG1-991 Reproduction QH471-489
Zdroj:	Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-8 (2024)
Druh dokumentu:	article
ISSN:	1477-7827
DOI:	10.1186/s12958-024-01278-8
Popis:	Abstract Objective Our aim was to explore the relationship between serum uric acid (UA) levels in early pregnancy and the development of gestational diabetes mellitus (GDM), and to further explore whether there is a causal relationship. Methods 684 pregnant women with GDM and 1162 pregnant women without GDM participated in this study. 311 pregnant women with GDM and 311 matched controls were enrolled in a 1:1 case-control study. We used conditional logistic regression to explore the relationship between UA levels and the risk of developing GDM. The causal relationship between the two was examined by two-sample Mendelian randomization (MR) analysis. Results In the 1:1 matched population, the odds ratio (OR) of developing GDM compared with the extreme tertiles of UA levels was 1.967 (95% confidence interval [CI]: 1.475–2.625; P
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