| Autor: |
Diana Souza de Oliveira, Maykelin Fuentes Zaldívar, Ana Alice Maia Gonçalves, Lucilene Aparecida Resende, Reysla Maria da Silveira Mariano, Diogo Fonseca Soares Pereira, Ingrid dos Santos Soares Conrado, Mariana Amália Figueiredo Costa, Daniel Ferreira Lair, Diego Fernandes Vilas-Boas, Eiji Nakasone Nakasone, Ingrid de Sousa Ameno, Wanessa Moreira Goes, Denise Silveira-Lemos, Alexsandro Sobreira Galdino, Ronaldo Alves Pinto Nagem, Walderez Ornelas Dutra, Rodolfo Cordeiro Giunchetti |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Vaccines, Vol 12, Iss 3, p 271 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2076-393X |
| DOI: |
10.3390/vaccines12030271 |
| Popis: |
The development of prophylactic vaccines is important in preventing and controlling diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for public health. Despite the efforts to develop a vaccine against human VL caused by Leishmania infantum, none is available, and the focus has shifted to developing vaccines against canine visceral leishmaniasis (CVL). Currently, commercially available vaccines are targeted at CVL but are not effective. Different strategies have been applied in developing and improving vaccines, such as using chimeric proteins to expand vaccine coverage. The search for patents can be a way of tracking vaccines that have the potential to be marketed. In this context, the present work presents a summary of immunological aspects relevant to VL vaccine development with a focus on the composition of chimeric protein vaccines for CVL deposited in patent banks as an important approach for biotechnological development. The resulting data could facilitate the screening and selection of antigens to compose vaccine candidates with high performance against VL. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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