| Autor: |
Theresa A. Shapiro, Gary H. Posner, Nirbhay Kumar, Bryan T. Mott, Vandana Singhal, Lauren E. Woodard |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Pharmaceuticals, Vol 2, Iss 3, Pp 228-235 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1424-8247 |
| DOI: |
10.3390/ph2030228 |
| Popis: |
Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariainfected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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