| Autor: |
Fei Ran Li, Maxime Lévesque, Siyan Wang, Maria-Isabel Carreño-Muñoz, Graziella Di Cristo, Massimo Avoli |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Current Research in Neurobiology, Vol 6, Iss , Pp 100131- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2665-945X |
| DOI: |
10.1016/j.crneur.2024.100131 |
| Popis: |
Catamenial epilepsy, defined as a periodicity of seizure exacerbation during the menstrual cycle, affects up to 70 % of epileptic women. Seizures in these patients are often non-responsive to medication; however, our understanding of the relation between menstrual cycle and seizure generation (i.e. ictogenesis) remains limited. We employed here field potential recordings in the in vitro 4-aminopyridine model of epileptiform synchronization in female mice (P60–P130) and found that: (i) the estrous phase favors ictal activity in the entorhinal cortex; (ii) these ictal discharges display an onset pattern characterised by the presence of chirps that are thought to mirror synchronous interneuron firing; and (iii) blocking estrogen receptor β-mediated signaling reduces ictal discharge duration. Our findings indicate that the duration of 4AP-induced ictal discharges, in vitro, increases during the estrous phase, which corresponds to the human peri-ovulatory period. We propose that these effects are caused by the presumptive enhancement of interneuron excitability due to increased estrogen receptor β-mediated signaling. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
