| Autor: |
Linfeng Gao, Yiran Guo, Mahamaya Biswal, Jiuwei Lu, Jiekai Yin, Jian Fang, Xinyi Chen, Zengyu Shao, Mengjiang Huang, Yinsheng Wang, Gang Greg Wang, Jikui Song |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-31933-w |
| Popis: |
In mammals, de novo DNA methyltransferase DNMT3B is essential for establishing DNA methylation patterns during embryonic development. Here the authors provide a structure-function characterization of homo-oligomeric DNMT3B, revealing the molecular basis for its vulnerability to ICF mutations. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink