| Autor: |
Reshma Kassanjee, Mary-Ann Davies, Alexa Heekes, Hassan Mahomed, Anthony J. Hawkridge, Erna Morden, Theuns Jacobs, Cheryl Cohen, Harry Moultrie, Richard J. Lessells, Nicolette Van Der Walt, Juanita O. Arendse, Nicole Wolter, Sibongile Walaza, Waasila Jassat, Anne von Gottberg, Patrick L. Hannan, Daniel R. Feikin, Keith Cloete, Andrew Boulle |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Vaccines, Vol 12, Iss 6, p 628 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2076-393X |
| DOI: |
10.3390/vaccines12060628 |
| Popis: |
There are few data on the real-world effectiveness of COVID-19 vaccines and boosting in Africa, which experienced widespread SARS-CoV-2 infection before vaccine availability. We assessed the association between vaccination and severe COVID-19 in the Western Cape, South Africa, in an observational cohort study of >2 million adults during 2020–2022. We described SARS-CoV-2 testing, COVID-19 outcomes, and vaccine uptake over time. We used multivariable cox models to estimate the association of BNT162b2 and Ad26.COV2.S vaccination with COVID-19-related hospitalization and death, adjusting for demographic characteristics, underlying health conditions, socioeconomic status proxies, and healthcare utilization. We found that by the end of 2022, 41% of surviving adults had completed vaccination and 8% had received a booster dose. Recent vaccination was associated with notable reductions in severe COVID-19 during periods dominated by Delta, and Omicron BA.1/2 and BA.4/5 (sub)lineages. During the latest Omicron BA.4/5 wave, within 3 months of vaccination or boosting, BNT162b2 and Ad26.COV2.S were each 84% effective against death (95% CIs: 57–94 and 49–95, respectively). However, distinct reductions of effectiveness occurred at longer times post completing or boosting vaccination. Results highlight the importance of continued emphasis on COVID-19 vaccination and boosting for those at high risk of severe COVID-19, even in settings with widespread infection-induced immunity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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