| Autor: |
Tomasz Kmiołek, Gabriela Filipowicz, Diana Bogucka, Anna Wajda, Adam Ejma-Multański, Barbara Stypińska, Ewa Modzelewska, Yana Kaliberda, Marcin Radkowski, Tomasz Targowski, Julia Wrona, Agnieszka Paradowska-Gorycka |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Immunity & Ageing, Vol 20, Iss 1, Pp 1-10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1742-4933 |
| DOI: |
10.1186/s12979-023-00384-2 |
| Popis: |
Abstract Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatric conditions with overlapping phenotypes. Many mechanisms are involved in the aging process such as DNA methylation telomeres which are susceptible to oxidative stress, and inflammations which result in telomere shortening, leading to chromosomal instability. The study aimed to determine the associations between these processes, frailty and sarcopenia syndrome. Global DNA methylation was analyzed using the ELISA method. Telomere length was analyzed using qPCR. Total oxidative status (TOS) was analyzed using a colorimetric method. The present study revealed that the main factor affecting methylation, telomeres length and level of total oxidant stress was age. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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