| Autor: |
Alan J. Twomey, Donagh P. Berry, Ross D. Evans, Michael L. Doherty, David A. Graham, Deirdre C. Purfield |
| Jazyk: |
German<br />English<br />French |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-17 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1297-9686 |
| DOI: |
10.1186/s12711-019-0457-7 |
| Popis: |
Abstract Background Quantitative genetic studies suggest the existence of variation at the genome level that affects the ability of cattle to resist to parasitic diseases. The objective of the current study was to identify regions of the bovine genome that are associated with resistance to endo-parasites. Methods Individual cattle records were available for Fasciola hepatica-damaged liver from 18 abattoirs. Deregressed estimated breeding values (EBV) for F. hepatica-damaged liver were generated for genotyped animals with a record for F. hepatica-damaged liver and for genotyped sires with a least one progeny record for F. hepatica-damaged liver; 3702 animals were available. In addition, individual cow records for antibody response to F. hepatica on 6388 genotyped dairy cows, antibody response to Ostertagia ostertagi on 8334 genotyped dairy cows and antibody response to Neospora caninum on 4597 genotyped dairy cows were adjusted for non-genetic effects. Genotypes were imputed to whole-sequence; after edits, 14,190,141 single nucleotide polymorphisms (SNPs) and 16,603,644 SNPs were available for cattle with deregressed EBV for F. hepatica-damaged liver and cows with an antibody response to a parasitic disease, respectively. Association analyses were undertaken using linear regression on one SNP at a time, in which a genomic relationship matrix accounted for the relationships between animals. Results Genomic regions for F. hepatica-damaged liver were located on Bos taurus autosomes (BTA) 1, 8, 11, 16, 17 and 18; each region included at least one SNP with a p value lower than 10−6. Five SNPs were identified as significant (q value |
| Databáze: |
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| Externí odkaz: |
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