Implications of Identifying Additional Cerebral Metastases during Gamma Knife Radiosurgery
| Autor: | Toral R. Patel, Ali K. Ozturk, Jonathan P. S. Knisely, Veronica L. Chiang |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | International Journal of Surgical Oncology, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2090-1402 2090-1410 |
| DOI: | 10.1155/2012/748284 |
| Popis: | Introduction. Gamma Knife radiosurgery (GK-SRS) is commonly used to treat cerebral metastases. Although additional intracranial metastases are often found on the day of GK-SRS, the significance of finding them is unknown. Methods. A retrospective review of 133 patients undergoing GK-SRS for cerebral metastases was performed. The change in number of metastases detected between initial referral magnetic resonance imaging (MRI) and subsequent treatment MRI was quantified. Multivariate and Kaplan-Meier analyses were employed to examine the significance of identifying additional lesions. Results. Additional lesions were identified in 41% of patients. An increasing number of metastases on referral MRI (𝑃=0.001) and the presence of progressive systemic disease (𝑃=0.003) were predictive of identifying additional metastases. Median survival was 6.9 months for patients with additional metastases, compared to 12.1 months for patients without additional metastases (hazard ratio 1.56, 𝑃=0.021). Conclusions. Identifying additional metastases on the day of GK-SRS may add important prognostic information. |
| Databáze: | Directory of Open Access Journals |
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