Complete response to larotrectinib treatment in a patient with papillary thyroid cancer harboring an ETV6‐NTRK3 gene fusion

Autor: Fabián Pitoia
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical Case Reports, Vol 9, Iss 4, Pp 1905-1912 (2021)
Druh dokumentu: article
ISSN: 2050-0904
DOI: 10.1002/ccr3.3900
Popis: Abstract Larotrectinib, a highly selective TRK inhibitor, was administered to a patient with rapidly progressing radioactive iodine‐refractory papillary NTRK3 fusion‐positive thyroid cancer. The patient achieved a durable (sustained for 11 months) complete response after 2 months of treatment and complete intracranial responses in metastatic brain lesions after 7 months of treatment. Larotrectinib may provide a therapeutic route for patients with RAI‐R‐differentiated thyroid cancer who might otherwise have few treatment options.
Databáze: Directory of Open Access Journals
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