Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
| Autor: | Hadi Sutopo, Fenska Mona Dwi, Noviany Noviany, Satria Heri, Simanjuntak Wasinton, Naseer Muhammad Moazzam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Main Group Metal Chemistry, Vol 44, Iss 1, Pp 256-260 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0792-1241 2191-0219 |
| DOI: | 10.1515/mgmc-2021-0028 |
| Popis: | This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|