| Autor: |
Hiromu Okano, Ryosuke Furuya, Shoko Niida, Sakura Minami, Hiroshi Horiuchi, Naoya Suzuki, Tsuyoshi Otsuka, Hiroshi Miyazaki |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Acute Medicine & Surgery, Vol 9, Iss 1, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2052-8817 |
| DOI: |
10.1002/ams2.782 |
| Popis: |
Aim This study compared the clinical outcomes of critically ill patients with coronavirus disease (COVID‐19) pneumonia treated with high‐dose methylprednisolone and other steroids. Methods This retrospective observational study included critically ill COVID‐19 pneumonia adult patients with tracheal intubation treated between April 1, 2020, and September 15, 2021. Of the 46 patients who met the inclusion criteria, 36 received steroid pulse therapy (Group P) and 10 received steroids without pulse therapy (Group NP). Subgroup analyses in Group P by methylprednisolone dose of 1000 or 500 mg for 3 days during intensive care unit stay were carried out. The primary and secondary outcomes were 28‐day mortality and steroid‐associated complications, respectively. Results In the Kaplan–Meier curve analysis, there was no difference in the 28‐day survival between P and NP groups (log–rank P = 0.046). Univariate Cox proportional hazard model also showed that Group P had a decreased 28‐day mortality (hazard ratio 0.30; [95% confidence interval, 0.20–0.44]; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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