A sex-oriented analysis concerning skeletal muscle quantity and quality and associations to quality of life in hospitalized patients with cirrhosis

Autor: Jie Yang, Gaoyue Guo, Fang Yang, Chaoqun Li, Han Wang, Wanting Yang, Ziyi Yang, Qing Liu, Qian Li, Chao Sun
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Health and Quality of Life Outcomes, Vol 22, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 1477-7525
DOI: 10.1186/s12955-024-02295-2
Popis: Abstract Background There is a paucity of data regarding sex-oriented analyses of connection between muscle quantity and quality and health-related quality of life (HRQoL), taking into account the pathophysiological differences of sarcopenia/myosteatosis in males versus females. We sought to investigate the associations between skeletal muscle index (SMI)-defined sarcopenia and intramuscular adipose tissue content (IMAC)-defined myosteatosis and EuroQol-5D (EQ-5D)-defined HRQoL in patients with decompensated cirrhosis concerning sex disparities. Methods Totally, 382 patients were enrolled. The relationship between SMI/IMAC and HRQoL was evaluated with restricted cubic spline and Pearson correlation analyses. Furthermore, association between SMI or sarcopenia and EQ-5D utility index was determined by multiple linear regression, adjusted for age, BMI and concurrent disease severity. Results The study population comprised evenly distributed male and female patients (190: 192), mean age 61.9 years. The prevalence of sarcopenia (40.5 versus 9.9%, P
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