On the feasibility of producing Lu-177 in the IEA-R1 reactor via the direct route

Autor: Guilherme Soares Zahn, Frederico Antonio Genezini, Paulo Sérgio Cardoso da Silva, Renata Mendes Nory, Edson Gonçalves Moreira, Paulo Sérgio Santiago
Jazyk: English<br />Portuguese
Rok vydání: 2021
Předmět:
Zdroj: Brazilian Journal of Radiation Sciences, Vol 9, Iss 1A (2021)
Druh dokumentu: article
ISSN: 2319-0612
DOI: 10.15392/bjrs.v9i1A.1411
Popis: Over the last years the 177Lu radioisotope has attracted great interest for the use in therapeutic and diagnostic procedures simultaneously, being what is now called a theranostic radioisotope. There are mainly two ways of producing this radioisotope, by direct neutron capture in a 176Lu target (the “direct route") or by irradiating a 176Yb sample, producing 177Yb that will then decay to 177Lu (also referred as the “indirect route”). In this work the feasibility of producing 177Lu in the IEA-R1 nuclear reactor via the direct route was assessed, and the specific activity that could be obtained was estimated both experimentally and theoretically, allowing for a discussion on the feasibility of commercially producing 177Lu by 176Lu neutron capture in the IEA-R1 reactor.
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