A Functional Polymorphism (rs6265, G>A) of Brain-Derived Neurotrophic Factor Gene and Breast Cancer: An Association Study

Autor:	Mehir un Nisa Iqbal, Tahniyat Yaqoob, Syed Adnan Ali, Taseer Ahmed Khan
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Breast Cancer: Basic and Clinical Research, Vol 13 (2019)
Druh dokumentu:	article
ISSN:	1178-2234 11782234 73691267
DOI:	10.1177/1178223419844977
Popis:	Purpose: The objective of this study was to evaluate the relationship between brain-derived neurotrophic factor (BDNF) gene (Val66Met, rs6265, G>A) polymorphism and breast cancer (BC) among females of Southern Pakistan. Methods: This case-control study consisted of 300 females (BC cases [n = 100] and controls [n = 200]) with age range of 18 to 45 years. All participants were recruited during January to December 2014 and were screened for depression using Zung depression scale. Isolation of genomic DNA (gDNA) followed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was done. All statistical analysis was carried out on IBM-SPSS version 22 at P -value
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d73691267fff416394a457c96355176c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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