Carascynol A, a hybrid of caryophyllane-type terpenoid and a C6 unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

Autor: Ya-Li Hu, Xing-Ren Li, Gang Xu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 12, Iss 1, Pp 1-5 (2022)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-022-00362-z
Popis: Abstract Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C6 unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray diffraction data. Biologically, compound 1 inhibited cell proliferation in LoVo, SW480, and HCT116 cell lines (IC50 = 12.30–24.57 µM). Graphical Abstract
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