Primary immature teratoma in the liver with growing teratoma syndrome and gliomatosis peritonei: a rare case report

Autor: RenMing Liu, JianNing Chen, ChunKui Shao, Na Cheng
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Diagnostic Pathology, Vol 17, Iss 1, Pp 1-7 (2022)
Druh dokumentu: article
ISSN: 1746-1596
DOI: 10.1186/s13000-022-01267-8
Popis: Abstract Background Primary liver immature teratoma is extremely rare and only 4 cases have been reported, let alone with growing teratoma syndrome (GTS) and/or gliomatosis peritonei (GP). Case presentation Here, we report a case of a 44-year-old female presenting with progressive abdominal distension and elevated serum alpha fetal protein (AFP) level. CT/MRI scans revealed a large cystic-solid mass in the right lobe of the liver, accompanied with implant or metastasis in the abdominal cavity. Pathologic examination at biopsy suggested immature teratoma. After 4 cycles of chemotherapy, an MRI showed a slight increase in tumor size. Therefore, surgical resection of the right lobe of the liver was performed. The final histological diagnosis was a mature teratoma (tumor size 28 cm × 14 cm × 13 cm), with no residual immature component, and the diagnosis of GTS was considered. The patient continued to receive 2 courses of postoperative chemotherapy. An abdominal CT scan revealed innumerable miliary nodules in bilateral adnexal areas 2 months after surgery. Histologically, large numbers of mature glia were observed, supporting the diagnosis of GP. Conclusions We report for the first time a case of primary liver immature teratoma with GTS and GP in an adult. Longer follow-up is needed to assess definitive efficacy.
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