Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts

Autor: Kunal Mahajan, Prakash Chand Negi, Neeraj Ganju, Sachin Sondhi, Naresh Gaur, Rao Somendra
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Hypertension, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2090-0384
2090-0392
DOI: 10.1155/2020/1025913
Popis: The functional receptor to SARS-CoV-2, the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, is angiotensin-converting enzyme-2 (ACE-2), the same enzyme that physiologically counters the renin-angiotensin system (RAS) activation. Some researchers have questioned RAS inhibitors’ safety in COVID-19 patients since these drugs have demonstrated an increase in ACE-2 expression in preclinical studies; therefore, they may facilitate viral invasion. On the contrary, others have hypothesized a protective role of RAS inhibitors against COVID-19-associated lung injury. Overall, the data are grossly inadequate to reach any conclusion since no human trials have yet evaluated the effects of RAS inhibitors in COVID-19. We review the current data and pathophysiological mechanisms behind this intriguing interplay between the RAS inhibitors and the COVID-19.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje